5-Amino-1MQ research peptide – 5-Amino-1MQ is a small-molecule NNMT inhibitor that raises N

5-Amino-1MQ

5-Amino-1MQ is a small-molecule NNMT inhibitor that raises NAD+ and SAM to support fat-cell metabolism, insulin sensitivity and healthy aging research.

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฿1700

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For research & laboratory use only. Not for human consumption.

Administration Route

Subcutaneous injection

NNMT Enzyme Inhibitor

Blocks fat cell programming enzyme to reverse obesity

Adipocyte Reprogramming

Converts white fat to metabolically active brown fat

NAD+ Pathway

Raises NAD+ by inhibiting methylation consumption

Mechanism of Action

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT normally consumes S-adenosylmethionine (SAM) to methylate nicotinamide into 1-methylnicotinamide, a reaction that drains both SAM and NAD+ from the cell. By blocking this enzyme, 5-Amino-1MQ keeps NAD+ and SAM available at the same time. Higher NAD+ activates sirtuins, especially SIRT1, while restored SAM supports the cell methylation cycle. In adipocyte models, NNMT inhibition lowers fat-cell differentiation and lipid accumulation, which is why the compound is studied as a NAD+ booster that works by reducing consumption rather than by adding a precursor.

Scientific Research

1
NNMT inhibition activates a futile cycle that reduces fat mass and improves insulin sensitivity

Nature Medicine (2013)

Why Researchers Choose 5-Amino-1MQ

5-Amino-1MQ is one of the few small-molecule NNMT inhibitors available for research, and it raises NAD+ by blocking consumption rather than by feeding a precursor. That distinct mechanism makes it useful across several lines of metabolic and longevity work:

  • NNMT enzyme biology and downstream metabolic pathway studies
  • NAD+ elevation mechanisms independent of NMN/NR precursor supplementation
  • S-adenosylmethionine (SAM) availability and methylation-cycle research
  • Adipocyte metabolism, fat-cell differentiation and lipid accumulation studies
  • Insulin sensitivity and glucose metabolism research
  • Comparative NNMT inhibition vs. NMN/NR booster protocols

Reconstitution and Storage

Reconstitution: use bacteriostatic water, or a 5 to 10% DMSO-in-water mix where greater solubility is needed. Swirl gently until dissolved, do not shake. After reconstitution: keep refrigerated and use within 14 days.

Dosing at a Glance

Route

Subcutaneous injection

Frequency

Once daily

Typical research dose

5–50 mg

Calculate dosage

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Product FAQs

Stacks Well With

NAD+

NAD+ (nicotinamide adenine dinucleotide) is the central redox coenzyme and sirtuin substrate used in cellular energy, DNA repair and anti-aging research.

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